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Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons

Identifieur interne : 000483 ( Main/Exploration ); précédent : 000482; suivant : 000484

Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons

Auteurs : Chi-Chung Tong [Hong Kong] ; Kwok-Hung Au [Hong Kong] ; Roger Kc Ngan [Hong Kong] ; Sin-Ming Chow [Hong Kong] ; Foon-Yiu Cheung [Hong Kong] ; Yiu-Tung Fu [Hong Kong] ; Joseph Sk Au [Hong Kong] ; Stephen Ck Law [Hong Kong]

Source :

RBID : PMC:3124409

Abstract

Background

To evaluate prognostic factors that may influence local control (LC) of T1N0 glottic cancer treated by primary radiotherapy (RT) with 6 MV photons.

Methods

We retrospectively reviewed the medical records of 433 consecutive patients with T1N0 glottic cancer treated between 1983 and 2005 by RT in our institution. All patients were treated with 6 MV photons. One hundred and seventy seven (41%) patients received 52.5 Gy in 23 fractions with 2.5 Gy/fraction, and 256 (59%) patients received 66 Gy in 33 fractions with 2 Gy/fraction.

Results

The median follow-up time was 10.5 years. The 10-year LC rates were 91% and 87% for T1a and T1b respectively. Multivariate analysis showed LC rate was adversely affected by poorly differentiated histology (Hazard Ratio [HR]: 7.5, p = 0.035); involvement of anterior commissure (HR: 2.34, p = 0.011); fraction size of 2.0 Gy (HR: 2.17, p = 0.035) and tumor biologically effective dose (BED) < 65 Gy15 (HR: 3.38, p = 0.017).

Conclusions

The negative impact of anterior commissure involvement could be overcome by delivering a higher tumor BED through using fraction size of > 2.0 Gy. We recommend that fraction size > 2.0 Gy should be utilized, for radiation schedules with five daily fractions each week.


Url:
DOI: 10.1186/1748-717X-6-53
PubMed: 21600025
PubMed Central: 3124409


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<title>Background</title>
<p>To evaluate prognostic factors that may influence local control (LC) of T1N0 glottic cancer treated by primary radiotherapy (RT) with 6 MV photons.</p>
</sec>
<sec>
<title>Methods</title>
<p>We retrospectively reviewed the medical records of 433 consecutive patients with T1N0 glottic cancer treated between 1983 and 2005 by RT in our institution. All patients were treated with 6 MV photons. One hundred and seventy seven (41%) patients received 52.5 Gy in 23 fractions with 2.5 Gy/fraction, and 256 (59%) patients received 66 Gy in 33 fractions with 2 Gy/fraction.</p>
</sec>
<sec>
<title>Results</title>
<p>The median follow-up time was 10.5 years. The 10-year LC rates were 91% and 87% for T1a and T1b respectively. Multivariate analysis showed LC rate was adversely affected by poorly differentiated histology (Hazard Ratio [HR]: 7.5,
<italic>p </italic>
= 0.035); involvement of anterior commissure (HR: 2.34,
<italic>p </italic>
= 0.011); fraction size of 2.0 Gy (HR: 2.17,
<italic>p </italic>
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<sub>15 </sub>
(HR: 3.38,
<italic>p </italic>
= 0.017).</p>
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<title>Conclusions</title>
<p>The negative impact of anterior commissure involvement could be overcome by delivering a higher tumor BED through using fraction size of > 2.0 Gy. We recommend that fraction size > 2.0 Gy should be utilized, for radiation schedules with five daily fractions each week.</p>
</sec>
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